The newer depression anxiety medications, especially the selective serotonin reuptake inhibitors (SSRIs), are generally preferred over the older medications.
Tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs), have more frequent and more severe potential side effects.
Both generations of depression anxiety medications are effective in relieving depression. The decision is usually made based on the expected side effects and how they impact the person's particular situation.
Some people will respond to one type of drug, but not another.
Bipolarity and Depression Anxiety Medication
It is critical to make sure that bipolarity is not a factor before using any of the above listed antidepressants.
Treating bipolar spectrum disorders with one of these medications can trigger mania, hypomania or severe irritability, anger outbursts or suicidal behavior.
Treating depression with a mood stabilizer, on the other hand, will not do harm, may help or may not have any effect. It is the safest pharmacological approach.
Bipolarity is more likely in people who
have a family history of bipolar disorder,
have had failures on standard depression anxiety medications,
have had adverse reactions to standard antidepressants,
have had a long course of illness,
and have experienced mania or hypomania.
It is not necessary to have had a manic or hypomanic episode to have a bipolar spectrum disorder.
Other medications sometimes used in combination with depression anxiety medications, to improve their effectiveness:
Thyroid hormone preparations: used to improve thyroid function. Depression can sometimes be a result of a low functioning thyroid gland, and this can help a lot.
Lithium: this is a mood stabilizer that can work together with other medications to get better resolution of symptoms.
Stimulants: these can sometimes be effective in depression where sedation and drowsiness are a major problem, but must be used with caution.
Precautions
In studies of nine depression anxiety medications, there was an increase in suicidal thinking and behavior in children and teenagers.
This may be due to the use of these drugs in misdiagnosed bipolar disorders.
Patients who are started on therapy should be observed closely for clinical worsening, suicidal thinking or behavior, or other unusual changes in behavior.
Adult and pediatric patients taking antidepressant medications should be watched closely for signs that their condition is getting worse or that they are becoming suicidal.
This is especially important when therapy is first started, or when their dose is increased or decreased.
Patients should also be watched for increases in agitation, irritability, hostility, impulsivity, or restlessness.
Such symptoms should be reported to the patient's prescriber right away.
When people suddenly stop using or quickly lower daily doses of any depression anxiety medications, discontinuation symptoms may occur.
Talk to your prescriber before discontinuing or reducing your dose of any medication.
Pregnant or nursing women shouldn't take any antidepressant without consulting their obstetric or pediatric provider.
Before starting any of the depression anxiety medications, tell your prescriber about any medicines you're taking.
This means any over-the-counter drugs, herbal supplements or naturopathic remedies.
Until you see how the antidepressant medications affect you, be careful doing such activities as driving a car or operating machinery.
Drug Interactions
People taking MAOIs should not take other antidepressants that act as serotonin or norepinephrine reuptake inhibitors.
Some depression anxiety medications may raise blood pressure in some patients.
Your blood pressure should be controlled before starting treatment and should be monitored regularly.
Avoid drinking alcohol while taking antidepressants. Alcohol is a depressant of the central nervous system, and can interact negatively with antidepressant drugs.
Also, taking a depression anxiety medication, and then opposing that chemical action with a depressant (alcohol) is counter productive.
It just doesn't make much sense to be using it when you are trying to get rid of the depression!
Adverse Side Effects
Some common side effects of antidepressants are
constipation,
dizziness,
dry mouth,
insomnia,
loss of appetite,
nausea,
nervousness,
sexual side effects,
sleepiness,
sweating,
and weakness.
Ask your prescriber about the specific side effects of the drug being considered for you.
Some studies have shown a relationship between SSRIs and suicidal behavior.
For this reason, anyone taking
depression anxiety medications
must be closely monitored by the prescribing professional until safety is assured.
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